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The real name of Deadpool is Wade Wilson and he was a mercenary in New York. He ends up diagnosed with terminal cancer and someone approaches him to enter a program that maybe will cure his cancer. However, he ends up tortured and the serum ends up cured.
The issue is that he ends up disfigured because of that. He tries to obtain vengeance and in doing so, he kills all the enemies. But he ends up disfigured without any way to revert it.